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《Shanghai Medical Journal》 2004-01
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Study of the effect of quercetin on expression of multidrug resistant gene and protein in K562/A02 cells

ZHONG Hua,GU Chunhong,TENG Ye,et al. Renji Hospital, Shanghai Second Medical University, Department of Hemotology, Shanghai,200001  
Objective To observe the effect of quercetin on expression MDR1 gene and protein in K562/A02 cell line and to discuss the possiblity of its clinical use.Methods Treated the cultured K562/A02 cells with or without various concentrations of quercetin (0.5~100 μmol/L). After 24 h, detected the expression of mdr1 gene by RT PCR and the Pgp contents with flow cytometry. Results 50-100 μmol/L of quercetin could downregulate the expression of mdr1 gene greatly. The Pgp analyzed by flow cytometry and fluorescence showed weaker expression on increased concentration of quercetin.Conclusions Quercetin can downregulate the expressions of mdr1 gene and Pgp in K562/A02 cells.
【CateGory Index】: R733.7
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