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《Shanghai Medical Journal》 2004-01
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Studies on superoxide dismutase isoenzyme activities and malondialdehyde levels in seminal fluid of infertile men

WANG Mingchen, YUAN Zhongfu, SONG liang, et al. Department of Biochemistry, Basic Medical College, Zhenzhou University, Henan 450052, China  
Objective To explore the effects of reactive oxygen species on the occurrence of male infertility. Methods The activities of superoxide dismutase isozymes (SODs) and the levels of malondialdehyde in the seminal fluid of 55 infertile men were determined respectively, and compared with those of 15 fertile men. Results The results showed that the total SOD (T SOD) and CuZnSOD activities in the groups with low or no vitality sperms,and sperm absent seminal fluid were significantly lower than those in the control group( P 0.05). Conclusions There exists metabolic disturbance of oxygen free radicals in patients with infertility. The low spermatic vitality is due to increase of lipoperoxidation and decrease of antioxidant activity. Increment of antioxidation activity may probably improve the vitality and spermatic function.
【CateGory Index】: R698.2
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