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《Shanghai Medical Journal》 2004-01
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Study of the plasma fibrinolysis system in patients with gynecologic malignancies

GU Xiaoping, LI Zhi, XU Binggen et al. Department of obstetrics and gynecology, Railway Hospital of Tongji university ,Shanghai 200072,China  
Objective The alterations of the fibrinolysis system were studied by measuring the activities and concentrations of plasminogen activator(PA),plasminogen activator inhibitor(PAI) and D dimer.Methods The items were determined by the enzyme linked immunoassay and substrate luminescence in 57 patients with gynecologic malignancies and 30 non cancer female patients.Results The activity and concentration of t PA in gynecologic malignancies were significantly increased comparing with those of the control group ( P 0.01), D dimer concentration was higher in cancer patients than that in non cancer patients ( P 0.05). Whereas the activity and concentration of PAI in gynecologic malignancies were significantly decreased comparing to those of the control group ( P 0.01).Conclusion The plasma fibrinolysis system has significant changes in patients with gynecologic malignancies which may be related to the progression of cancerous process。It is important to study further more the relationship between the alterations of the fibrinolysis system and metastasis of gynecologic cancer.
【CateGory Index】: R737.3
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 Tang Huibin; Zhou Zhongweng; Zhang Xiaohua; Sun Dongfeng; Song Houyan; Zhu Yunsong (Department of Molecular Genetics, School of Basic Medical Sciences 200032, Department of Pathology, Huashang Hospital, Shanghai Medical University, Shanghai 200040);EXPRESSION OF TYPE-1 PLASMINOGEN ACTIVATOR INHIBITOR IN BREAST CARCINOMA TISSUES[J];ACTA ATADEMIAE MEDICINAE SHANGHAI;1996-03
【Co-citations】
Chinese Journal Full-text Database 1 Hits
1 Tang Huibin,He Cheng,Liao Jinhui,et al.(Department of Molecular Genetics,Shanghai Medical University, Shanghai 200032);EXPRESSION OF PLASMINOGEN ACTIVATORS (t PA,uPA/uPAR) AND INHIBITOR PAI 1 IN BREAST CANCER[J];CHINA ONCOLOGY;1999-03
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