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《Shanghai Medical Journal》 2007-01
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Pre-and postoperative changes of plasma interleukin-18 in patients with obstructive jaundice

FANG Lin, ZHU Qinghua, TENG Hongfei, HEJian, MENG Hongbo, ZHENG Lijun, XU Lei, MAO Yukan. Department of General Surgery, Shanghai 10th People's Hospital, Tongji University , Shanghai 200072, China  
Objective To appraise the pre-and postoperative changes of plasma interleukin-18, immunoglobulin, and complements in patients with obstructive jaundice and their relationships. Methods Twenty-two patients with obstructive jaundice were operated and taken as the operative group. Their pre-and postoperative plasma samples were detected for the levels of interleukin-18, immunoglobulin G(IgG), IgA, IgM, complement C3, C4, CH50 were also detected. Fourteen patients with normal serum bilirubin were taken as the control group and the results of the two groups were compared. Results The level of postoperative plasma interleukin-18 was higher than the preoperative level, but the levels of postoperative plasma IgG, CH50, C3, C4 were lower. The levels of interleukin-18 were negatively correlated with IgG, CH50, C3, but with no relationship with C4. Conclusion Operation may affect plasma interleukin-18 level in patients with obstructive jaundice, showing negative correlation with IgG, CH50, C3. Interleukin-18 may pose more influence on immune function of these patients.
【Fund】: 国家自然科学基金资助项目(30370650)
【CateGory Index】: R657.4
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