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《Shanghai Medical Journal》 2007-02
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DNA ploidy and Ki67 expression in eyelid basal cell carcinoma

CHEN Qianhe, ZHANG Jie, ZHU Wei. Department of Ophthalmology, Shanghai Fifth People's Hospital, Fudan University , Shanghai 200240, China  
Objective To investigate the prognostic significance of DNA ploidy and Ki67 expression in eyelid basial cell carcinoma. Methods A total of 23 cases of eyelid basal cell carcinoma were studied for the expression of Ki67 by immunohistochemistry, and DNA ploidy determined by image cytometer(ICM). Results Of the 23 cases of eyelid basal cell carcinoma, DNA aneuploidy was seen in 15 cases (65. 2%), presenting as 90% in recurrent basal cell carcinoma following treatment but it was only 37. 5% in nonrecurrent cases, this difference was statistically significant (P = 0. 043). The labeling indexes of Ki67 expression were 0. 272±0. 134 in recurrent tumors vs 0. 197±0. 019 in nonrecurrent ones. There was a notable increase in the percentage positive for Ki67 in recurrent tumors as comparing with the nonrecurrent tumours, showing no statistical significance (P = 0. 069). Conclusions Aneuploidy in eyelid basial cell carcinoma would be probably a warning sign for recurrences, arousing for corresponding treatment.
【CateGory Index】: R739.7
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