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《Shanghai Medical Journal》 2012-01
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Efficacy and safety of a novel non-symmetrical,biodegradable polymer-coated sirolimus-eluting stent in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention

*ZHENG Yuhua,ZHOU Binquan,ZHANG Feng,QIAN Juying,GE Lei,FAN Bing,WANG Qibing,HUANG Dong,MA Jianying,YAO Kang,GE Junbo.*Department of Cardiology,Sir Run Run Shaw Hospital,Medical School of Zhejiang University,Hangzhou 310016,Zhejiang,China  
Objective To compare a novel non-symmetrical,biodegradable polymer-coated sirolimus-eluting stent(NSBP-SES) with a traditional symmetrical,durable polymer-coated sirolimus-eluting stent(SDP-SES) during percutaneous coronary intervention(PCI),and to evaluate its efficacy and safety in patients with ST-segment elevation myocardial infarction(STEMI).Methods From January 2007 to December 2009,NSBP-SES was implanted in 171 patients(experimental group) and SDP-SES in 249 patients(control group) during primary PCI for STEMI.All the patients were followed up for one year postoperatively.Results There was no significant difference in the incidence rate of 12-month target lesion failure(TLF) between experimental group and control group(5.8% vs.5.6%,P0.05);neither were the death,cardiac death,non-fatal re-infarction,target vessel revascularization,or target vessel failure(all P0.05).Subacute stent thrombosis occurred in 1 patient in experimental group and in 3 patients in control group.Late stent thrombosis occurred in another patient in control group.Conclusion There are no significant differences in efficacy and safe between NSBP-SES and SDP-SES during primary PCI for STEMI.Further investigation is warranted to validate the long-term clinical outcomes.
【Fund】: 国家自然科学基金(81101133);; 上海市青年科技启明星(跟踪)计划项目(11QH1400500);; 上海市卫生系统优秀青年人才计划项目(XYQ2011001)资助
【CateGory Index】: R542.22
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1 LI Yanlin,SHI Haiming,LUO Xinping,Itsik Ben-Dor,Rebecca Torguson,Zhenyi Xue,Joseph Lindsay,Augusto D. Pichard,Ron Waksman. Department of Cardiology,Huashan Hospital,Fudan University,Shanghai 200040,China;Drug-eluting stents for patients with acute coronary syndromes:an analysis of long term outcome[J];Shanghai Medical Journal;2010-05
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