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《Shanghai Medical Journal》 2012-09
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Correlation between macroelements and adverse reaction in patients with gastrointestinal cancer during chemotherapy

*HOU Lili, LI Min, WANG Xiaoli, XU Lei, SUN Wenqi. *Department of Hygieology, Second Military Medical University, Shanghai 200433, China  
Objective To investigate the correlation between serum microelement levels and chemotherapy tolerance in the patients with gastrointestinal cancer. Methods Totally 129 patients with gastrointestinal cancer admitted to the Department of General Surgery and Department of Oncology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine were enrolled in the study. The levels of serum microelements (sodium, potassium, calcium, chloride and magnesium) were measured on the day before chemotherapy. Adverse reaction after chemotherapy was recorded. The microelement levels were compared between the patients with and without adverse reaction. Results The serum calcium level in the patients with systemic adverse reaction was significantly lower than those without adverse reaction (P0.05). Serum calcium level was negatively correlated with systemic adverse reaction, adverse reaction of digestive system and total adverse reaction caused by chemotherapy (r=-0.29, -0.19, and -0.21, respectively, P0.05), so was the serum calcium level (r=-6.86, -2.53, and -2.66, respectively, P0.05). But serum magnesium level before chemotherapy was positively correlated with adverse reaction of the digestive system (r=0.64, P0.05). Conclusion There is close correlation between the levels of serum macroelements and adverse reaction in patients with gastrointestinal cancer during chemotherapy. It is suggested that nutrition guidance and macroelement adjustment should be taken in order to reduce the adverse reaction and improve patient′s tolerance.
【Fund】: 上海市卫生局科研基金资助项目(2005L019A)
【CateGory Index】: R735
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