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《Journal of Shihezi University(Natural Science)》 2005-01
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The Changes of Na~+-K~+-ATPase Activity in the Erythrocyte Member of Patients with Type Ⅱ Diabetes with Diabetic Nephropathy

LIU Chun~1, YANG Xiao-ping~1, MA Ya-jing~2, ZHOU Zu-zao~3, WU Xi-xiong~2, ZHANG Jin-ping~1, CHENG Hong-xin~1, SHI Xin-hui~1(1 Department of Nephrology,1st Affiliated Hospital,Shihezi University,Shihezi,Xinjiang 832008,China;2 Department of clinical laboratory,1st Affiliated Hospital,Shihezi University,Shihezi,Xinjiang 832008,China;3 Department of Medicine,College of Medicine,Shihezi University,Shihezi,Xinjiang 832002,China;)  
To measure Na~+-K~+-ATPase activity in the erythrocyte member of patients with type 2 diabetes with diabetic nephropathy in different stage,so as to provide theoretical bases for some clinical diagnoses and treatment.51 patients were divided into 3 groups including normoalbuminuric group(DM_1 group),microalbuminuric group(DM_2 group) and macroalbuminuric(DM_3 group). Normal control group was made of 20 subjects including 11 men and 9 women,average age being 58.27±10.89 .The blood samples were withdrawn in control group and tested group to detect Na~+-K~+-ATPase activity in the erythrocyte member.The results showed that Na~+-K~+-ATPase activity in erythrocyte member was significantly lower in each group than that of the control group (P=0.001).It demostrated that Na~+-K~+-ATPase activity in erythrocyte member was decreased in diabetic nephropathy. The controlling of blood glucose and remaining of Na~+-K~+-ATPase activity had important significance to improve diabetic nephropathy.
【CateGory Index】: R587.1
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