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《Journal of Shihezi University(Natural Science)》 2010-01
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A Comparison of Polarization Caused by GABA in Normal and Neuropathic Pain Rat DRG Neurons

LI Li,ZHAO Yanchang,WANG Lei,ZHANG Tian,CHENG Hongju,CAO Yingying,SI Junqiang (Medical College of Shihezi University,Shihezi 832003,China)  
The role of γ-aminobutyric acid(GABA) in neuropathic pain was observed and the effects of GABA on pain transmission explored.Isolated L4-L5 dorsal root ganglion(DRG) from the rat of neuropathic pain model,used intracellular microelectrode recording technique to observe the membrane potential changes of DRG neurons caused by the perfusion of GABA receptor and its antagonist.The depolarization induced by different concentrations of GABA in the neuropathic pain model group were significantly less than that in the normal control group(P0.05).Neuropathic pain can facilitate the pain transmission by reduces GABA-mediated presynaptic inhibition.
【CateGory Index】: R741
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【Co-citations】
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1 ZHOU Qi-zhi,ZHAO Ji-lan,CAI Ding-jun,YU Shu-guang,WEI Jiao-lu,WU Qiao-feng,PENG Xiao-hua,WANG Wei,XU Hai-yang(Laboratory of Acu-moxibustion,College of Acu-moxibustion and Tuina,Chengdu University of TCM,Chengdu 610075,China);Regulation effects of electro-acupuncture on monoamine neurotransmitter and GABA in rats with chronic emotional stress-induced anxiety[J];China Journal of Traditional Chinese Medicine and Pharmacy;2008-10
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