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Separation and purification of propionic acid(PA)from fermentation broth using ion- exchange method hold great application promise for PA fermentation and vitamin B12 fermentation.An appropriate resin,Resin C was selected from more than 20 types of resins.The static state absorption capacity of Resin C from 1.2 % PA solution and from fermentation broth containing 2.0 % PA were 494.3 g/kg and 140.18 g/kg wet resin respectively.The dynamic state exchange trials,in- cluding adsorption,elute and regeneration of resin,were performed.Preliminary study implied that feeding fluid flow rate had significant effect on the course of PA ion- exchange.
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