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《Progress In Physiological Sciences》 2003-01
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Proteins Regulating Neurotransmitter Release of Synaptic Vesicles at Nerve Terminals

CAI Qian 1, LU Pei Hua 1△ , SHENG Zu Hang 1, 2△ ( 1 Department of Neurobiology, Shanghai Second Medical University, Shanghai 200025; 2 Synaptic Function Unit, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892, USA)  
Neurotransmitter release of synaptic vesicle at nerve terminals is a complicated and elaborately regulated process, involving a cascade of protein protein interactions. The SNARE core complex consisting of synaptobrevin/VAMP (a synaptic terminal protein), syntaxin and SNAP 25 (synaptic membrane associated proteins), acts as the membrane fusion machinery and plays essential roles in synaptic vesicle exocytosis. This review will discuss proteins with potential roles in synaptic vesicle exocytosis by regulating assembly, disassembly and the function of SNARE complex, and sum up the molecular model of vesicle exocytosis.
【Fund】: 国家海外、香港青年学者合作研究基金课题 (3 992 80 0 1)
【CateGory Index】: Q189
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