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《Progress In Physiological Sciences》 2003-01
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Capsaicin and Its Receptor——Vanilloid Receptor

LUO Hao, WAN You, HAN Ji Sheng (Neuroscience Research Institute and Department of Neurobiology, Peking University, Beijing 100083)  
The detection of painful stimuli occurs primarily at the peripheral terminals of specialized sensory neurons called nociceptors. These small-diameter neurons transmit this information to the central nervous system, ultimately eliciting a perception of pain or discomfort. The capsaicin (vanilloid) receptor, an excitatory ion channel expressed at nociceptors, plays an important role in transducing thermal and inflammatory pain. Mice lacking the VR1 gene have deficits in thermal or inflammation induced hyperalgesia, which confirms the involvement of this channel in pain sensation, especially the sensation of heat evoked pain.
【Fund】: 国家自然科学基金(3 983 0 160和 3 0 170 3 19);; 国家重点基础研究计划“脑功能和脑重大疾病的基础研究”(G19990 5 40 0 0 )资助课题
【CateGory Index】: Q42
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