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《Progress In Physiological Sciences》 2003-01
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Alterations of G Proteins in Heart Diseases

ZHANG Liang, LI Li, WU Li Ling (Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100083)  
Guanine nucleotide binding proteins (G proteins), known as an important signal transduction molecular, can physiologically couple extracellular signals identified by G protein coupled receptors (GPCRs) to a series of intracellular effector to cause changes of gene transcription and protein's structure and function. Members of G protein family including Gs, Gi/o, Gq/11, and G12/13 express in the myocardium. In the heart G protein mediated signal transduction generates diverse effects on myocardiac contractility, heart rate, heart rhythm, and myocyte growth. This review focuses on alterations of G protein in cardiac hypertrophy, heart failure, acute myocardial ischemia, and arrhythmia to help us to understand the pathogenesis and pathophysiology in heart diseases.
【Fund】: 北京大学“985”创新型医学人才培养工程基金;; 国家自然科学基金 (3 0 170 3 79)资助课题
【CateGory Index】: R363
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