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《Progress in Physiological Sciences》 2006-01
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Roles of Vasodilator-stimulated Phosphoprotein in the Regulation of Cytoskeleton

WANG Ting-Ting,LI Ke,WEI Lei(Department of Pathophysiology,Medical College of Wuhan University,Wuhan 430071,China)  
Regulation of cytoskeletal dynamics is required to coordinate cell adhesion,morphology change and cell motility.Vasodilator-stimulated phosphoprotein(VASP) is an actin-binding protein which is composed of EVH1,EVH2 domains and PRR.It has been implicated in actin-based processes such as axon guidance,T cell polarization and fibroblast migrations.The regulation of VASP phosphorylation,which is controlled by PKG(cGMP-dependent protein kinase) and PKA(cAMP-dependent protein kinase),could correspond to the " switch " process in its communication with cytoskeleton during modification of focal adhesion.
【Fund】: 国家自然科学基金(30570751);; 教育部留学归国人员科研基金(301170272);; 湖北省自然科学基金(301130890)资助课题
【CateGory Index】: R363
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