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Progress in Study on Organic Anion Transporters

SONG Bi-Wei,ZHOU Yan-Jun(Dept of Pharmacology,College of Pharmaceutical Science,Zhejiang University of Technology,Hangzhou 310014,China)  
Organic anion transporters(OATs) belong to a family of poly-specific transporters mainly located in barrier epithelia such as renal proximal tubule,brain,liver and placenta.OATs interact with endogenous metabolic end products such as urate and acidic neutrotransmitter metabolites,as well as with a multitude of widely used drugs,including antibiotics,diuretics,antihypertensives and anti-inflammatory drugs.Thereby,OATs play an important role in renal drug elimination and have an impact on pharmacokinetics.This review summarizes current knowledge of the properties and functional roles of the cloned OAT family members detailed in tissue differences in expression and physiologic function,drug-drug interactions,and finally,gender-dependent regulation in health and diseased states.
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