Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Progress in Physiological Sciences》 2014-01
Add to Favorite Get Latest Update

Lipoprotein Lipase and Diabetic Cardiomyopathy

LIU Xiang-Yu;YIN Wei-Dong;TANG Chao-Ke;Institute of Cardiovascular Disease,Key Laboratory for Atherosclerology of Hunan Province,University of South China;D School of Pharmacy and Life Science University of South;  
Lipoprotein lipase( LPL) hydrolyzes plasma triglyceride-rich lipoproteins into free fatty acids( FFA) to provide energy for cardiac tissue. During diabetes,cardiac energy supply is insufficient due to defected utilization of glucose. As a compensation of cardiac energy supply,FFAs are released through the hydrolysis of very low density lipoprotein( VLDL) and chylomicrons( CM) due to activation of LPL activity. In diabetic patients,activated LPL activity and elevated FFAs result in the intracellular accumulation of reactive oxygen species and lipids in myocardium and potentially induce the diabetic cardiomyopathy( DCM). The present review summarizes the regulatory mechanisms of myocardial LPL and the pathogenesis of DCM induced by LPL and provides novel therapeutic targets and pathways for DCM.
【Fund】: 国家自然科学基金(81270269 81170278 81070220)资助课题
【CateGory Index】: R587.2
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved