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Endothelium Aging and Oxidative Stress

CHEN Bo;LU Yan-Rong;CHEN You-Nan;KANG Yu-Jian;CHENG Jing-Qiu;Key Laboratory of Transplant Engineering and Immunology,Ministry of Health,Regenerative Medicine Research Center,West China Hospital,Sichuan University;Department of Human Anatomy,School of Basic Medical Sciences,Luzhou Medicine College;  
In the endothelium,ROS mainly derive from mitochondria,endothelial nitric oxide synthases and NADPH oxidases 4. Excessive ROS are a major cause of oxidative stress,the primary stimulus of vascular dysfunction and oxidative stress-related diseases. However,cellular evolution has made possible the development of adaptive antioxidant systems that scavenge excessive ROS,such as Nrf2 / Keap1-ARE,PPARγ,SIRT and FOXO,etc. Among them,the Nrf2 / Keap1-ARE signaling pathway is perhaps the most prominent. What is more,there are the " crosstalk" among these antioxidant stress-related signaling pathways aim to alleviate oxidative stress injurys and promote cells survival. The understanding of the relationship between endothelial aging and oxidative stress may serve as a therapeutic clues in the treatment of oxidative stress-related diseases.
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