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The Function of Neuroinflammation in Parkinson Disease

LI Jun-Yu;MA Shan-Shan;HUANG Qiao-Ying;LI Ming-Tao;Department of Pharmacology,Zhongshan School of Medicine,Sun Yat-sen University;  
Parkinson disease( PD) is the second most common neurodegenerative disorder,characterized by a progressive loss of dopaminergic neurons in the substantia nigra( SN). The pathology of PD remains unclear. Recent findings suggests neuroinflammation plays a critical role in PD. Occurrence of neuroinflammation,including microglia and astrocyte activation,T lymphocyte infiltration and blood-brain barrier disruption,has been identified in PD. However,the mechanism of neuroinflammation regulation in PD is not fully deciphered. In this review,we focus on the cutting edge in researches of neuroinflammation in PD,which may provide us new ideas in prevention and recovery of PD.
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