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Parkinson Disease With Rapid Eye Movement Sleep Behavior Disorder

HU Yang;ZHANG Wei;Department of Neurology,Beijing Tiantan Hospital,Capital Medical University;Department of Geriatrics,Beijing Tiantan Hospital,Capital Medical University;China National Clinical Research Center for Neurological Diseases;Center of Parkinson's Disease,Beijing Institute for Brain Disorders;Beijing Key Laboratory on Parkinson Disease;  
Rapid eye movement( REM) sleep behavior disorder( RBD) is characterized by lack of muscle atonia during REM sleep and enactment of dream content. RBD is associated with Parkinson disease( PD) and has high incidence in PD patients. PD patient with RBD mainly presents rigid type,has longer disease duration,more severe motor and non-motor symptoms and poorer activity of daily living and life quality. The pathophysiological mechanisms of RBD may be related to dysfunctions of pontine tegmentum,locus coeruleus / sub-locus coeruleus complex and related projections. The diagnosis of RBD depends on clinical histories and video-polysomnography( v-PSG). Besides treatment for PD,protective measures have to be taken for patients and their sleep partners. If abnormal behaviors during sleep cause distress and danger,patients should be given drug therapy.
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