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《Progress in Physiological Sciences》 2016-01
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PPARs Mediate the Regulation of Energy Metabolism By Long-Chain Fatty Acids

YAO Yan;WANG Zong-Bao;TANG Chao-Ke;Institute of Cardiovascular Disease,Key Laboratory for Atherosclerology of Human Province,University of South China;School of Pharmacy and Life Science University of South;  
PPAR-alpha expressed primarily in liver is essential for metabolic adaptation to starvation by inducing genes for beta-oxidation and ketogenesis to increase the utility of LCFAs and fibroblast growth factor 21. PPAR-delta induces genes for LCFA oxidation during fasting and endurance exercise in skeletal muscle. PPAR-delta also regulates glucose metabolism and mitochondrial biogenesis by inducing FOXO1 and PGC1-alpha. PPAR-gamma can induces the pathways to store LCFAs as triglycerides in adipocytes.Adiponectin,another important target of PPAR-gamma may maintain insulin sensitivity between adipocytes. The present review summarize that PPARs mediate the regulation of energy metabolism by longchain fatty acids.
【Fund】: 国家自然科学基金(81370377)资助课题
【CateGory Index】: R589
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