The Molecular Switches and Atomic Biological Mechanisms Underlying the Physiological and Pathophysiological Effects of Hydrogen Sulfide to Regulate Its " Receptors"
XUE Wen-Long;CAI Wen-Jie;TAO Bei-Bei;WANG Min-Jie;LI Xing-Hui;ZHU Yi-Chun;Shanghai Key Laboratory of Bioactive Small Molecules,Department of Physiology and Pathophysiology,School of Basic Medical Sciences,Fudan University;Department of Basic Medicine,College of Medical Instruments and Foodstuff,University of Shanghai for Science and Technology;
Hydrogen sulfide( H_2S) has emerged as pivotal signaling molecules since it is recognized as the third gasotransmitter together with nitric oxide and carbon monoxide. The development of detecting technologies contributed to the research in H_2S biology. H_2S plays significant roles in human body systems,such as the cardiovascular system,nervous system,respiratory system etc.. Alterations of H_2S concentrations have been connected with many diseases. Hypertension,atherosclerosis,neurodegenerative disorder,asthma and many other diseases are found to be related with abnormal H_2S metabolism. It has become a potential drug for therapeutic purposes. Understanding the mechanism of H_2S biology,including a molecular switch contained in its " receptor",has deepened the research on how small molecules regulate big molecules,as well as providing new strategy for the therapeutic approaches for varies of diseases.