Adipocytic Endogenous Hydrogen Sulfide-Function,Regulation and Diseases
GENG Bin;Hyper-tension Center,Fuwai Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,State Key Laboratory of Cardiovascular Disease;
Hydrogen sulfide( H2S) is a novel gastrotransmitter,and plays a protective role in many diseases. Adipocyte endogenously produces H_2S by cystathionine β synthase( CBS),cystathionine γ lyase( CSE) and 3-mercaptopyruvate sulfurtransferase( MPST). The endogenous H_2S in adipocyte plays an essential role in glucose uptake activity and utilization,lipolysis and adipocyte differentiation,and then takes part in the pathogenesis of obesity,diabetes and cardiovascular diseases. H_2S regulates adipocyte energy metabolism by activation activating insulin receptor,peroxisome proliferator activated receptor γ( PPARγ) or potassium channel. H_2S acts as an " energy switch" in regulation of metabolic diseases.