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Nitric Oxide Signaling Pathway and Vascular Activity

GAO Yuan-Sheng;Department of Physiology and Pathophysiology of Peking University Health Science Center;  
Nitric oxide-cyclic guanosine 3',5'-monophosphate(cGMP)-cGMP dependent protein kinase signaling pathway is a key mechanism for the modulation of vascular function. The progress in this area of recent years was briefly summarized in this article,in particular,regarding the redox-dependent dimerization of the relevant signaling molecules and their physiological significance as well as the role of soluble guanylyl cyclase-derived cyclic inosine 3',5'-monophosphate as a new messenger for vasoconstriction.
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