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《PROGRESS IN PHYSIOLOGICAL SCIENCES》 1995-01
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Psychoneuroimmunological Effects of Morphine and the Immunoprotection of Ganoderma Polysaccharides Peptide in Morphine-dependent Mice

Lu Zheng-Wu(Department of Pharmacology, School of Basic Medical Sciences, Beijing Medical University, Beijing 100083)  
Different kinds of single, multiple, acute or chronic administrations of morphinized animal models were established, with which a series of experiments in both in vivo and in vitro systems as well as molecular levels were pharmacologically designed to investigate the psychoneuroimmunological effects of morphine(Mor)and the immunoprotection of Ganoderma polysaccharides peptide(GPP) in Mor-dependent mice.It was first discovered that both c-myb and c-myc e mRNA expression in splenocytes of repititive Mor-treated mice were detected to be significantly decreased, and that GPP could induce restoration of several immunologic parameters depressed by Mor treatment to or even beyond normal levels.This provides the experimental animal evidence that immune response modifiers such as GPP could be of potential application in controlling abuse of opiates-induced immunodeficiency.
【CateGory Index】: R967
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【References】
Chinese Journal Full-text Database 1 Hits
1 FENG Peng1,2,3,SHEN Jian3,LIU Cheng3,WU Dong1,SUN Yu-han1(1.Institute of Coal Chemistry,Chinese Academy of Sciences,Taiyuan 030001,China;2.Graduate School of the Chinese Academy of Sciences,Beijing 100039,China;3.Nanjing Zhongke Group Co.,Ltd,Nanjing,210008,China);Study of the Immunemodulation Effect of Ganoderma Spore Polysaccharide(Ⅱ)[J];时珍国医国药;2007-12
【Citations】
Chinese Journal Full-text Database 3 Hits
1 Lu Zhengwu Lin Zhibin( Department of Pharmacology,Sohool of Basic Medical Sciences,Heijing Medical University );Effects of Morphine on Phagocytosis, Cytotoxicity and Cytokines Production of Macrophages in Mice[J];基础医学与临床;1994-05
2 LU Zheng-Wu, LIN Zhi-Bin ( Department of Pharmacology, Beijing Medical University, Beijing, 100083);CHANGES OF IMMUNE RESPONSE OF MORPHINE-ADDICTED MICE[J];中国药物依赖性通报;1994-01
3 LS Lei and ZB Lin (Department of Pharmacology, Beijing Medical University, Beijing 100083, China);EFFECTS OF GANODERMA POLYSACCHARIDES ON THE ACTIVITY OF DNA POLYMERASE α OF SPLENOCYTES AND IMMUNE FUNCTION IN AGED MICE[J];药学学报;1993-08
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 CHEN Yang-yang;LIU Kun-na;LI Yun-jiao;DU Jia-feng;HUO Chao;SANG Ya-xin;College of Food Science of Technology,Agricultural University of Hebei;College of Food Science of Technology,Agricultural University of Hebei,College of Biological Engineering;;Effect of exopolysaccharides from Lactobacillus paracasei VL8cooperated with Con A on spleen lymphocyte proliferation and induction of cytokine in mice[J];食品工业科技;2017-15
2 SHI Chen-shan;SUN Gui-qing;WU Rui-xia;GONG Zheng-si;WANG Xiang-hong;Department of Food Science and Technology,Agricultural University of Hebei;Hebei Ocean and Fisheries Science Research Institute;;Primary Structural Characterization and Cell Immunomodulatory Activity of a Non-agar Polysaccharide Obtained from Gracilaria Lemaneiformis[J];现代食品科技;2016-07
3 MAO Hui-hui;YOU Yu-hong;Department of Pharmacology,School of Pharmacy,Fujian Medical University;;Protective effect of ganoderma lucidum polysaccharides peptide on cultured neonatal rat cardiomyocytes injured by hypoxia / reoxygenation[J];中国药理学与毒理学杂志;2015-03
4 SHI Chen-shan;SUN Gui-qing;ZHANG Ya-zhuo;WANG Yu;WANG Xiang-hong;College of Food Science and Technology, Agricultural University of Hebei;Hebei Ocean and Fisheries Science Research Institute;;Effects of alkali treatment on the extraction of Gracilaria lemaneiformis non-agar polysaccharide and in vitro immune activity[J];食品科技;2015-03
5 HUANG Guo-zhen 1 CHEN Wei-bu 2 LI Li-mei 1 HUANG Xin-min 1 1.People's Hospital of Pingshan New District in Shenzhen City in Guangdong Province,Shenzhen 518118,China; 2.People's Hospital of Shenzhen City in Guangdong Province,Shenzhen 518001,China;Lipoteichoic acid of Bifidobacterium activate macrophages to produce TNF-α signaling pathway[J];中国当代医药;2013-21
6 CHEN Yue-yuan,SUN Li-ping. The Graduate School of Changchun University of Traditional Chinese Medicine,Changchun 130117,China;Experimental research into the influence of Yiqi Guben capsule on the spleen lymphocyte proliferation function and organ index in the kidney-Yang deficiency asthma model mice[J];中国中西医结合儿科学;2013-01
7 DENG Yang-yong,WU Can-rong,YANG Xu-li,et al(Xiangtan Vocational and Technical College,Xiangtan,Hunan 411100,China);Effect of Aloe Polysaccharide on Thymic Tissue of Senile Mice[J];中南医学科学杂志;2011-06
8 Shi Yali1,Cai Dehua2,Gao Xingxi 2 1 College of Physical Education,LuDong University,YanTai,China 264025 2 Institute of Mycological Science and Technology,LuDong University,YanTai,China 264025;Effects of Ganoderma Lucidum Polysaccharide on Macrophages Activity and Functions in Long-term High Intensity Exercise Mice[J];中国运动医学杂志;2011-04
9 WANG Yuhua1,2,3,TAO Yimin3,CHEN Jie3,XU Xuejun3,CHI Zhiqiang3,LIU Jinggen31(School of Pharmacy,China Pharmaceutical University,Nanjing,210009,China)2(School of Pharmacy,Nanjing University of Chinese Medicine,Nanjing,210046,China)3(State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai,201203,China);EFFECTS OF JITAI TABLETS ON IMMUNE FUNCTIONIN MORPHINE DEPENDENT MICE[J];中国药物依赖性杂志;2011-01
10 ZHU Ke-xue,NIE Shao-ping,LI Wen-juan,YU Qiang,ZHANG Shen-shen,XIE Ming-yong (State Key Laboratory of Food Science and Technology,Nanchang University,Nanchang 330047,China);Effect of Polysaccharides from Ganoderma atrum on Spleen Lymphocyte Proliferation and Induction of Cytokine in Mice[J];食品科学;2010-19
【Co-references】
Chinese Journal Full-text Database 3 Hits
1 LIANG Zhong qin, SHENG Wei hua, GU Zhen run, YANG Ji cheng (Suzhou Medical College, Suzhou 215007, China);Regulation Effect of Water-extraction from Ganoderma Lucidum (Lyess.ex Fr) karst. on Human Immune cells and IL-6[J];中成药;2000-12
2 Mao Junhao,Lu Zhiliang,Zeng Qunli,Ruan Hong (Department of Biological Science and Technology,Zhejiang University,Hangzhou 310027);Effects of the polysaccharide of Atractylis macrocephala Koidz on the function of mouse T lymphocyte[J];免疫学杂志;1996-04
3 Lu Zheng-Wu(Department of Pharmacology, School of Basic Medical Sciences, Beijing Medical University, Beijing 100083);Psychoneuroimmunological Effects of Morphine and the Immunoprotection of Ganoderma Polysaccharides Peptide in Morphine-dependent Mice[J];生理科学进展;1995-01
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 SONG Yu-xian,DOU Huan,LIU Xian-qin,GONG Wei,HOU Ya-yi (Immunology and Reproductive Biology Lab of Medical School of Nanjing University,Nanjing 210093,China);The Effects of Ganoderma Lucidum Spore Oil on MCF-7 Cell Apoptosis and Migration[J];中医药信息;2011-02
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