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Control of Growth and Expression of Protooncogenes in Regenerating Liver

ZOU Yuan;GONG De-Zheng;CUI Xiu-Yun;MEI Mao-Hua(Department of Physiology,Department of Biochemistry,Dalian Medical University, Dalian 116023)  
There are many humoral factors involved in the control of growth in regenerating liver.The complete hepatocyte mitogens such as hepatocyte growth factor(HGF),hepatic stimulator substance(HSS)can strongly stimulate hepatocyte DNA synthesis and mitosis.The hepatocyte growth inhibitors such as transforming growth factor β1(TGFβ1),however,do not stimulate DNA synthesis.but inhibit EGF mitogenesis. In addition,the comitogens such as norepinephrine and insulin are necessary to regulate the growth of regenerating liver.It has become clear that the hepatocyte proliferation and protooncogenes are linked closely.Some protooncogenes can express specifically as markers in the different phases of the cell cycle and in hepatocytes that enter the cell cycle(G0 to G1 transit)and continue to progress.
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