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G Proteins-Pheephoinositide Pathwsys in Hypertension

HU Shen-Jiang,HUANG Yuan-wei,Li Ying(Cardiorscular Depariment,The First Affiliated Hospital,Zhejiang Medical Unirersity,Hangzhou 310003)  
The second messenger inositol-l,4,5-trisphosphate(InsP3)comes from two major pathways,one is initiated by a family of G protein-linked receptors-and the other by receptors linked by tyrosine kinases.These separate receptors activate phospholipase C to hydrolyse phosphatidylinositol-4,5-bisphosphate to give both diacylgycerol and Insp3.The latter,then mobilizes stored calcium and promotes dn influx of external calcium.The a subunit of a newly discovered G protein(Gq)has recently been shown to stimulate the activity of PLC-β1.The a subunits of the Gq class of G proteins include,Gαq,Gα11.Gα14,Gα15 and Gα16.The important pathologic changes in hypertension are arteriolar spasm and wall thichening.Many vasoactive substances can induce contractile response and proliferaion of vascular smooth muscle cells and increase InsP3 level.However,the hypertension does not cause any persistent chage in Gq.
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