Development of Calcium Fluorescent Probes and Their Application in Life Sciences
ZHANG Chuan-Li,WU Ben-Jie(Department of
Biophysics,Beijing Medical University,Beijing 100083)
t is
well known that calcium is the key second intracellular
messenger.Techniques using calcium fluorescent probes have been
rapidly developed during the last decade,and have become one of the
most important methods to measure intracellular free
ca2+concentrations. This trend was even more accelerated after the
development of a new generation of calcium fluorescent probes and the
laser scanning confocal microscopy In this article we will review the
development of calcium fluorescent probes,the mechanisms and methods
of measuring intracellular free ca2+ concentrations,the properties of
new calcium fluorescent probes, and their applications in life
sciences.
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