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Direct Modulatory Effects of G Proteins on Voltage Dependent Ion Channels of Nerve Cells

WU Xin Sheng, HE Shu Fang (Shanghai Brain Research Institute, Chinese Academy of Sciences,Shanghai 200031)  
Neurotransmitters have regulative effects on voltage dependent ion channels of nerve cells. Recent studies have shown that voltage dependent channels were modulated by transmitters through direct interactions between G proteins and channels without any known second messengers being involved.This gave us a novel understanding of the relations between G proteins and voltage dependent ion channels.This article reviews the phenomena, characteristics, and mechanisms about voltage dependent channels modulated by transmitters through direct effects of G proteins.
【CateGory Index】: Q51
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