The Key Enzyme of Cholesterol Synthesis Pathway:HMG CoA Reductase and Disease
WANG Wei,TONG Tan Jun (Department of biochemistry and molecular biology,Beijing Medical University,Beijing 100083)
In eukaryotes, 3 hydroxy 3 methylglutaryl coenzyme A (HMG CoA) reductase is a key enzyme that catalyses the synthesis of a precusor of cholesterol as well as non sterol isoprenoids,mevalonate. The regulation of the enzyme activity occurs at the transcription, post transcription, translation and protein degradation levels. Cholesterol contributes to the generation and development of atherosclerosis while non sterol isoprenoids play a role in regulation of cell proliferation, signal transduction and generation of cancers.At present,the enzyme is the target of several drugs effective against atherosclerosis.