The Signal Transduction of Cell Activation by LPS:The Studies from CD14 to p38 MAPK
JIANG Yong,ULEVITCH RJ △ (Key Laboratory for Shock and Microcirculation of PLA, The First Military Medical University, Guangzhou 510515; △ Department of Immunology, The Scripps Research Institute, CA 92037,USA)
Recently there have been some substantial progresses in signal transduction of cell activation by lipopolysaccharide (LPS). After binding with LBP in the plasma, LPS is transported to the cell membrane surface of monocytes, then binds with membrane CD14 to induce cell activation. Mitogen activated protein kinases (MAPKs) take part in the signal transduction of LPS stimulated cell activation to produce bioactive substances including tumor necrosis factor. p38 MAPK is an important regulator for TNF α expression. It is possible to provide new theory and idea for the treatment of septic shock from the studies of signal transduction of cell activation by LPS.