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《MEDICAL JOURNAL OF QILU》 1998-01
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DETERMINATION OF D-DIMER AND GMP- 140 IN PATIENTS OF NON-INSULIN DEPENDENT DIABETES MBLLITUS WITH ISCHEMIC CEREBROVASCULAR DISEASE

Zhang Chen, Zhao Renliang, Zhao Huiyuan, et al Department of Neu- rology, The Affiliated Hospital of Qingdao Medical College, Qingdao 266003 [  
Objective To investigate the pathogenesis of ischemic cerebrovascular diesease in patients suffering from non- insulin-dependent diabetes mellitus (NIDDM). Methods The plasma concentcation of D-dimer, GMP-140 and GMP-140 expressed on the sucface of activated plateletes were detecdted in NIDDM patients complicated with ischemic cerebrovascular dis- ease by using the enzyme-linked immunosorbent assay and the radioimmunoassay. Results The plasma levels of D-dimer, GMP- 140 and GMP-140 on the surface of activated plateletes in patients of NIDDM complicated with arteriosclerosis or cecebral throm- bosis aod patients with single cerebral thrombosis were higher than those in the control group (t=5.25 - 20. 04 , P 0. 001). While the above indeces showed no significant difference in patients with single cerebral arterioaclerosis. A serial study found that the levels of D-dimer and GMP-140 were decreased in the rehabilitate state of single cerebral thrombosis patients (t= 5. 25- 7.05, P0. 001), But the levels of D-dimer and GMP-140 in the rehabilitate state of NIDDM patients with cerebral thrombosis were not decreased significantly compared with those of acute state patients (t= 1.42 - 1.99, P0.05). Conclusion The results of the study suggested that enhanced activity of coagulation and fibrinolysis and highly activated plateletes were risk factors for patients of NIDDM to develop ischemic cerebcovascular disease. [
【CateGory Index】: R587,R743
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Chinese Journal Full-text Database 1 Hits
1 Long Jie, Qu Hui, Bai Yun, et al. Department of Neurology, Beijing Tian Tan Hospital, Beijing 100050;The fluctuation of t PA and PAI 1 activity in patients with cerebral thrombosis, and their clinical significance[J];CHINESE JOURNAL OF NEUROLOGY;1998-05
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