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《MEDICAL JOURNAL OF QILU》 1998-01
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A CORRELATIVE STUDY OF PLASMA LCAT ACTIVITY AND LIPOPROTEIN AND RED BLOOD CELL MEMBRANE LIPID COMPOSITIONS IN PATIENTS WITH CEREBRAL INFARCTION

Zhao Renliang, Wang Chunxia, Mu Xiaofeng, et al De- partment of Neurology, The Affiliated Hospital of Qingdao Medical College, Qingdao 266003 [  
Objective To investigate the relationships between plasma lecithin cholesterol acyltransferase ( LCAT) ac- tivity and lipoprotein and red blood cell membrane (RBCM) lipid compositions in patients with cerebral infarction (CI). Methods LCAT activity was determined by a method of exogenous substrate in 48 cases of CI and 36 normal controls, high density lipopro- tein cholesterol (HDL-C) and its subgroups (HDL2-C, HDL3-C), low density lipoprotein cholesterol (LDL-C), apolipopratien A-1 and B CapoA-1 , apoB). RBCM-cholesterol (RBCM-CH) and RBCM-phospholipd (RBCM-PL) were also measured. Results LCAT activity decreased significantly in CI group; Compositions of plasma HDL-C, HDL2-C and apoA-1 were also reduced signifi- cantly; Compositions of plasma LDL-C, apoB, RBCM-CH and the ratio of RBCM-CH/RBCM-PL increased significantly(t=2.24 -3. 25, P 0. 05 - 0. 01). Moreover, LCAT activity correlated positively with HDL-C, HDL2-C , apoA-1(γ=0. 384,0. 298, 0. 319;P0. 01,0. 05,0, 05). and negitively correlated with LDL-C, RBCM-CH(r= -0. 290, -0. 323; P 0. 05). Conclu- sion Abnormal lipid metabollism in CI patients is correlated with decreased LCAT activity. [
【CateGory Index】: R743.3
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