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《Journal of Shanghai Ocean University》 2019-01
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Effects of pterostilbene on lipopolysaccharide-induced inflammatory cytokine expression in macrophages

YAO Yun;LIU Kehai;HU Xiaoqian;Food Science and Technology College,Shanghai Ocean University;Shanghai Engineering Research Center of Aquatic-Product Processing & Preservation;  
To evaluate the anti-inflammation effect of pterostilbene on RAW264. 7 macrophages, an inflammation model in vitro was established by lipopolysaccharide( LPS) stimulation. After exposing RAW264. 7 cells to pterostilbene and LPS,the mRNA expression of inflammatory cytokines including monocyte chemoattractant protein( MCP)-1,interleukin( IL)-6 and IL-1β,tumor necrosis factor( TNF)-α,and inducible nitric oxide synthase( i NOS) were detected by real-time quantitative polymerase chain reaction( q PCR). Nitric oxide( NO) production in supernatant was analyzed using Griess method. The protein expression of extracellular regulated protein kinases( ERK),c-Jun N-terminal kinase( JNK),p38 mitogenactivated protein kinase( p38 MAPK) and Nuclear factor-κB p65( NF-κB p65) were detected by Western blot analysis. The results showed that pterostilbene significantly inhibited the gene expression of inflammatory cytokines and the production of NO. Pterostilbene significantly suppressed LPS-induced ERK,p38 and p65 phosphorylation. Data showed that pterostilbene could inhibit the mRNA expression of LPS-induced inflammatory cytokines including MCP-1,IL-6,IL-1β,TNF-α and i NOS,and the release of NO,and its mechanism may be related to blocking the mitogen-activated protein kinase( MAPK) and NF-κB pathway.
【Fund】: 国家自然科学基金(31601559)
【CateGory Index】: TS218
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Chinese Journal Full-text Database 4 Hits
1 WANG Biao;YANG Ling-ying;ZENG Qing-you;School of Chemical Engineering,Huaqiao University;;Study on the synthesis of natural antioxidant Pterostilbene[J];应用化工;2015-03
2 PENG Jie1,HAN Xue-ying2,HU Xiao-yan3,DENG Jing-ti3,GUO Yuan1 (1.Department of Cardiology,Qilu Hospital of Shandong University,Jinan 250012,China;2.Shangdong Province Blood Center Jinan Blood Station,Jinan 250001,China;3.Department of Biochemistry and Molecular Biology,School of Medicine,Shandong University,Jinan 250012,China);The effect of resveratrol on expression of IL-1β,IL-6,MCP-1 and SOCS1/3 in human peripheral blood mononuclear cells[J];山东大学学报(医学版);2011-11
3 FU Guang-xin,JIANG Xian,LI Jia,et al.(Department of Oral Surgery,the First Affiliated Hospital of Luzhou Medical College,Luzhou 646000,China);THE EFFECTS OF RESVERATROL ON INFLAMMATORY CYTOKINES RELEASE FROM RAW 2647 CELLS INDUCED BY LPS[J];现代预防医学;2010-03
4 LIU Fang,QU Ji-bing,LI Hong,YANG Shi-jie~* (Department of Pharmacology,School of Medicine,Jilin University,Changchun 130021,China);Study on Anti-Inflammatory Mechanisms of Resveratrol[J];中国药学杂志;2006-15
Chinese Journal Full-text Database 10 Hits
1 LIU Li-xia;NIU Meng-li;WANG jing;Department of Pharmacy,Bayannaoer Hospital;;RESEARCH PROGRESS ON THE PLANT POLYSACCHARIDE OF ANTI-INFLAMMATORY MECHANISM[J];内蒙古医科大学学报;2015-S1
2 LIU Xin-yuan;LI Yue-ling;Baotou Medical College;;Anti-inflammatory effect and mechanism study of pig bile dry extract[J];青岛医药卫生;2014-02
3 ZHOU Jie-hui;JIN Ying-kai;XU Hai-hong;GAO Yang;LIN Wen-zhen;LIANG Shi-pai;ZHANG Zhen-jiang;ZHANG Shao-hui;Shanghai Jiao Tong University College of Agriculture and Biology;The Panda Dairy Co.Ltd.;Shanghai Jiao Tong University Bor S.Luh Food Safety Research Center;;Anti-inflammation effect and regulatory role on oxidative stress of a bioactive peptide[J];中国乳品工业;2014-03
4 SU Jun-hua;SHI Dong-yan;WANG Lei;LI Wei-hao;DU Su-ping;LI Yong-jun;Department of Clinical Laboratory,the Second Hospital of Hebei Medical University;Department of Clinical Laboratory,Gaoyang County Hospital of Hebei Province;Department of Gynecology and Obstetrics,the Second Hospital of Hebei Medical University;;In vitro antibacterial activity of resveratrol against Enterococcus[J];山东大学学报(医学版);2014-02
5 LUO Xiajiong;WANG Yuqian;LU Peili;WANG Jingyun;CHEN Xiaoxia;HE Bing;College of Pharmacy,Guangdong Pharmaceutical University;Guangdong General Hospital;;Effect of resveratrol on the production of inflammatory mediators in mice asthmatic model[J];广东药学院学报;2013-06
6 LIU Ping,LIU Yu-ping,TONG Ji-ming*(Hebei Province Key Laboratory of Research and Development for New Drugs,Institute of Chinese Materia Medica,Chengde Medical College,Chengde 067000,China);Anti-inflammatory Effect of Total Flavones of Trollius Ledebouri Reichb[J];中国实验方剂学杂志;2012-20
7 JIA Li-li1,2,LI Yuan-hong2,WU Yan2,LI Xiao-hong1,LIU Xiao-yuan1(1.Department of Dermatology,The Fourth Hospital of Ji Lin University,Changchun 130011,China;2.Department of Dermatology,The First Hospital of China Medical University,Shenyang 110001,China);Clinical observation the whitening efficacy and safety of resveratrol[J];中国美容医学;2012-09
8 GU Li-li1,2,LIU Li-ya1,MA Qin-qin1,ZHU Dan1,WANG Hui-ye1,HUANG Xiu-lan1(1.China Minority Traditional Medical Institute,Minzu University of China,Beijing 100081,China;2.Luoyang Vocational & Technical College,Luoyang 471001,China);Regulation of Resveratrol on the Apoptosis of Human Umbilical Vein Endothelial Cells Induced by Hydrogen Peroxide[J];时珍国医国药;2012-06
9 Tong Ji-ming , Liu Yu-ling , Chen Guang-hui (Key Laboratory of research and development of traditional Chinese medicine in Hebei province-Chengde Medical College Institute of traditional Chinese medicine,Chengde 067000,China);Experimental Study on the Anti-inflammatory Effects of Sanhuang Tablets[J];中国药物评价;2012-01
10 YU Xiao-min,LIU Yu-ling,LIU Yong-ping,TONG Ji-ming(Hebei Province Key Laboratory of Research and Exploiture on New Drugs from Chinese Materia Medica and Institute of Chinese Mateia Medica,Chengde Medical College,Chengde 067000,China);Experiment Study on Anti-inflammatory Effect of Total Saponins from Thladiantha dubia Root[J];中国实验方剂学杂志;2012-10
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 LI Chun-rong1 XU Zhong-liang2 WANG Hui2 WANG San-yong1(1.Guangdong Food Industry Institute,Public Lab of Guangdong Food Industry,Guangzhou 510308;2.School of Chemistry and Environment,South China Normal University,Guangzhou 510006);Synthesis of natural multifunction antioxidant Pterostilbene[J];中国食品添加剂;2007-03
2 WT4”,5BZ]XIAO Jun 1, CHE Zhun-tao 2, BI Kai-shun 1 (1. Shenyang Pharmaceutical University, Shenyang 110015, China; 2. School of Chinese Medicine, The Chinese University of Hong Kang, Shatin, N.T., Hong Kong, China) [WT4”,5HZ];PRE-COLUMN DERIVATIZATION HPLC METHOD FOR THE DETERMINATION OF ASIATICOSIDE IN CENTELLA ASIATICA AND SANJINPIAN[J];药学学报;2000-08
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