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《Journal of Shanghai Ocean University》 2019-01
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Effects of pterostilbene on lipopolysaccharide-induced inflammatory cytokine expression in macrophages

YAO Yun;LIU Kehai;HU Xiaoqian;Food Science and Technology College,Shanghai Ocean University;Shanghai Engineering Research Center of Aquatic-Product Processing & Preservation;  
To evaluate the anti-inflammation effect of pterostilbene on RAW264. 7 macrophages, an inflammation model in vitro was established by lipopolysaccharide( LPS) stimulation. After exposing RAW264. 7 cells to pterostilbene and LPS,the mRNA expression of inflammatory cytokines including monocyte chemoattractant protein( MCP)-1,interleukin( IL)-6 and IL-1β,tumor necrosis factor( TNF)-α,and inducible nitric oxide synthase( i NOS) were detected by real-time quantitative polymerase chain reaction( q PCR). Nitric oxide( NO) production in supernatant was analyzed using Griess method. The protein expression of extracellular regulated protein kinases( ERK),c-Jun N-terminal kinase( JNK),p38 mitogenactivated protein kinase( p38 MAPK) and Nuclear factor-κB p65( NF-κB p65) were detected by Western blot analysis. The results showed that pterostilbene significantly inhibited the gene expression of inflammatory cytokines and the production of NO. Pterostilbene significantly suppressed LPS-induced ERK,p38 and p65 phosphorylation. Data showed that pterostilbene could inhibit the mRNA expression of LPS-induced inflammatory cytokines including MCP-1,IL-6,IL-1β,TNF-α and i NOS,and the release of NO,and its mechanism may be related to blocking the mitogen-activated protein kinase( MAPK) and NF-κB pathway.
【Fund】: 国家自然科学基金(31601559)
【CateGory Index】: TS218
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【Citations】
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