Effect of aging on stem cells
Abu Shufian Ishtiaq Ahmed;Matilda HC Sheng;Samiksha Wasnik;David J Baylink;Kin-Hing William Lau;Regenerative Medicine Unit,Department of Medicine,Loma Linda University School of Medicine;Musculoskeletal Disease Center,Jerry L.Pettis Memorial VA Medical Center;
Pluripotent stem cells have the remarkable self-renewal ability and are capable of differentiating into multiple diverse cells. There is increasing evidence that the aging process can have adverse effects on stem cells. As stem cells age, their renewal ability deteriorates and their ability to differentiate into the various cell types is altered. Accordingly, it is suggested aging-induced deterioration of stem cell functions may play a key role in the pathophysiology of the various aging-associated disorders. Understanding the role of the aging process in deterioration of stem cell function is crucial, not only in understanding the pathophysiology of agingassociated disorders, but also in future development of novel effective stem cell-based therapies to treat agingassociated diseases. This review article first focuses on the basis of the various aging disease-related stem cell dysfunction. It then addresses the several concepts on the potential mechanism that causes aging-related stem cell dysfunction. It also briefly discusses the current potential therapies under development for aging-associated stem cell defects.
【CateGory Index】： R329.2