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《世界实验医学杂志(英文版)》 2017-01
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Discernment scheme for paraquat poisoning: A five-year experience in Shiraz, Iran

Saeed Kavousi-Gharbi;Reza Jalli;Akbar Rasekhi-Kazerouni;Zahra Habibagahi;Sayed Mahdi Marashi;Student Research Committee,Shiraz University of Medical Sciences;Medical Imaging Research Center,Shiraz University of Medical Sciences;Department of Internal Medicine,School of Medicine,Shiraz University of Medical Sciences;Trauma Research Center,Emergency Room,Division of Medical Toxicology,Hazrat Ali-Asghar(p)Hospital,Shiraz University of Medical Sciences;  
AIM To evaluate various schemes for paraquat poisoning and different variables that influence the outcome of acute paraquat poisoning.METHODS In a cross-sectional study, the information about all cases of acute paraquat poisoning who were admitted to teaching hospitals affiliated to Shiraz University of Medical Sciences, in a five year period(September 2010 to September 2015) were evaluated. The variables included: Demographic data, medical assessment, therapeutic options, laboratory findings, and the outcomes. Data were analyzed using SPSS, version 22. Significant difference between groups was tested using t-test for continues outcomes and χ~2 test for categorical. The significance level was considered to be P 0.05. RESULTS A total of 104 patients(66.3% male) were evaluated. The mean age of the female patients was 22.81 ± 9.87 years and the male patients' was 27.21 ± 11.06 years. Ninety seven(93.3%) of all the cases were suicide attempts with mortality rate of 43.2%. Despite the necessity for emergency hemodialysis during the first 6 h of intoxication, none of the patients had dialysis during this time. Immunosuppressive and corticosteroid medications were not administrated in adequate dosage in 31.1% and 60% of the patients, respectively. Ingestion of more than22.5 cc of paraquat and increase in creatinine level were the most important predictors of mortality.CONCLUSION Treatment should start immediately for these patients.Moreover, creating a clinical guideline according to the findings can have an impact on the treatment procedure which seems to be necessary.
【Fund】: Supported by Shiraz University of Medical Sciences
【CateGory Index】: R595.4
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【Co-references】
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1 WANG Luan;ZHAO Min;Department of Emergency,Shengjing Hospital of China Medical University;;Mechanism and Treatment of Acute Paraquat Poisoning[J];医学综述;2017-14
2 ZHU Dan;HE Yarong;YAO Rong;CAO Yu;Emergency Department of West China Hospital,Sichuan University;;Tacrolimus(FK506) alleviates inflammatory responses on paraqurat-induced ALI in rats[J];临床急诊杂志;2017-03
3 YANG Jing;LIU Shanshou;LI Junjie;HU Xiaomin;HUANG Yang;YIN Wen;Department of Emergency,Xijing Hospital,the Fourth Military Medical University of PLA;;Study of preventive and therapeutic effects of lipid emulsion combined with anisodamine for acute lung injury induced by paraquat poisoning[J];临床急诊杂志;2017-02
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