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Athletes' Diarrhea Occurrence and Changes of Intestinal Microbial Flora in High Altitude Training

HAN Tian-yu;HU Yang;ZHANG Wei-jia;LI Yan-chun;YU Jia-bei;Beijing Sport University;  
Objective: The purpose of this study was to investigate the incidence of diarrhea and the change in intestinal microbial flora during altitude training.Methods: To observe the gastrointestinal reaction and to statistically analyze the incidence rate and the timing characteristics of diarrhea in 64 long distance runners during Douba national altitude training camp.Meanwhile,feces samples of 15 middle/long distance runners from Liaoning Province team were taken before they arrived at altitude training camp and at the 5 time-point(immediately,3 rd,6 th,9 th and 12 th day) after their arrival.Every sample was routinely examined within 1 hour after sampling and whole genome DNA were extracted,and microbiological diversity in available DNA samples was analyzed by high throughput sequencing.Results: 1) In athletes during altitude training,the incidence rate of diarrhea rate was 46.7% and its duration time was less than 10 days,most of them(74.1%) less than 5 days.2) A high incidence of diarrhea cases are mainly concentrated in two periods,respectively in 1-3 days(35.7% of total diarrhea cases) and in 7-10 days(46.4% to total diarrhea cases) after arrived at altitude,there was no diarrhea case after 12 days.3) There is no significant difference in microbial diversity of before and after arrived at altitude.4) Bacteroidetes' proportion of the intestinal microflora first increased and then recovered,and its Firmicutes' proportion first decreased and then recovered during altitude training.Conclusions: 1) Diarrhea cases often occured in athletes during altitude training camp,showing two peak periods.2) After arrived at altitude,there was no significant change in intestinal microbial flora diversity.In phylum level,however,Bacteroidetes' proportion showed a trend from increase to regain its original level and Firmicutes' proportion showed a trend from decrease to recovery.
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