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Progress in Expandase and Its Prospects of Application

Chen Hui\ Han Hui\ Xu Guanzhu (Institute of Microbiology,the Chinese Academy of Science,Beijing,100080)  
Expandase,also referred to as deacetoxycephalosproin C sysnthetase,which catalyzes ring expansion of penicillin N to deacetoxycephalosporin C,is a rate\|limiting enzyme in the biosyntheis of cephalosporins.In fungus,expandase is a bifunctional enzyme and the expandase activity is always phaysically associated with DAOC hydroxylase activity,wherease in the case of bacteria, the expandase and hydroxylase activities are clearly spearated. Recent years,expansase has been purified to near homogeneity.And it has made rapid progress in the studies on expandase's biologial properties, structure of molecular and gene and so on. People have been continuously finding ways to apply these knowledge to the production of antibiotecs by the technology of genetic engineering.\;
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