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Advance on the Studies of Biodegradation of Aromatic compounds

Sun Yan\ Qian Shijun (Institute of Microbiology,Academia Sinica,Beijing\ 100080)  
Biodegradation of aromatic compounds such as benzene\,alkylbenzenes\,biphenyl and polycyclic aromatic hydrocarbons is reviewed.The conversion of them to cis \|diols and the ring\|cleavage by two kinds of dioxygenases are all involved in the pathway.The molecular biology research about the TOL\|pathway is also discussed here.Metabolic engineering is introduced into the aromatic compounds degradation in early 90's.In the pathway,rate\|controlling enzyme can be determined and the flux through the pathway increased by increasing the titer of the rate\|controlling enzyme.\;
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