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《Progress In Biotechnology》 2004-10
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Advances in Brain Targeting Drug Delivery

CHEN Chu-guang CHEN Hong HUANG Bing-ren (Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, PUMC, Beijing 100005, China)  
The blood brain barrier between the brain and the brain capillary endothelial cells is a impermeable barrier, which can prevent most aliens transport into brain. All of the neurotherapeutics that are used in clinical practice at present are small lipid soluble molecules that can diffuse through the BBB. Yet these drugs can no longer meet the clinical needs, many brain neurotherapeutics and neuroprotective drugs are large, water soluble molecules. The usual pathway to deliver large molecules into brain is ineffective and dangerous, therefore the study of brain targeting drug delivery has become a hotspot recent years. This article reviews the advances in brain targeting drug delivery technology such as chimeric peptide technology, PEGylated immunoliposome and nanoparticle technology.
【Fund】: 国家自然科学基金资助项目 (3 0 0 70 894)
【CateGory Index】: R452
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【Co-references】
Chinese Journal Full-text Database 5 Hits
1 Liu Qide; Liang Meirong; Chen ZhiXi;Feng Meirong; Zhao Ping(Clinical Pharmacology Laboratory);The Influence of Borneol on the Passing of Gentamycin Through Blood-Brain Barrier[J];;1994-01
2 LI Xingang ;HAO Xiaoguang;GUO Yuan et al (Department of Neurosurgey,The affiliated Hospital Shandongmedical University Jinan,250012);Interstitial chemotheyrapy with biodegradable Adriamycin-PLA polymer for C6 glioma model in rats[J];Chinese Journal of Neurosurgery;1999-06
3 LI Xingang, LI Liangmin, GUO Yuan, et al. Department of Neurosurgery, The Affiliated Hospital, Shandong Medical University, Jinan, 250012;The aggregation of lipid-coated microbubbles for a radi ofrequency lesion in the rat brain[J];CHINESE JOURNAL OF NEUROSURGERY;2000-02
4 GONG Song-feng, LI Xin-gang, LI Gang, et al. Department of Neurosurgery Qilu Hospital,Shandong University, Jinan 250012,China;Study of C6 glioma cell lines′ inhibition by Taxol carried by lipid-coated microbubbles in vitro[J];Chinese Journal of Neurosurgery;2005-08
5 Xu Wei; Wang Zhongrui(Guangdong Medical College, Zhanjiang 524023);Effect of menthol and borned on the distribution of sulfadiazine sodium andEvan's blue in the rat and mouse brain[J];PHARMACOLOGY AND CLINICS OF CHINESE MATERIA MEDICA;1995-06
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