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《Progress In Biotechnology》 2004-10
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Advances in Brain Targeting Drug Delivery

CHEN Chu-guang CHEN Hong HUANG Bing-ren (Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, PUMC, Beijing 100005, China)  
The blood brain barrier between the brain and the brain capillary endothelial cells is a impermeable barrier, which can prevent most aliens transport into brain. All of the neurotherapeutics that are used in clinical practice at present are small lipid soluble molecules that can diffuse through the BBB. Yet these drugs can no longer meet the clinical needs, many brain neurotherapeutics and neuroprotective drugs are large, water soluble molecules. The usual pathway to deliver large molecules into brain is ineffective and dangerous, therefore the study of brain targeting drug delivery has become a hotspot recent years. This article reviews the advances in brain targeting drug delivery technology such as chimeric peptide technology, PEGylated immunoliposome and nanoparticle technology.
【Fund】: 国家自然科学基金资助项目 (3 0 0 70 894)
【CateGory Index】: R452
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