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《China Biotechnology》 2009-08
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An Experimental Study on Using the Porous Composite of Nano-hydroxyapatite and Polymide as Scaffold Compound with rhBMP-2 to Repairing Bone Defect on Rabbits

MENG Chun-yang1 JIANG Dian-ming2 AN Hong2 HUANG Wei2 ZUO Yi3 LI Yu-bao3(1 Jining Medical College,Jining 272113,China)(2 The First Affiliated Hospital of Chong Qing University of Medical Sciences,Chongqing 400016,China)(3 Analytical and Testing Center,Sicuan University,Chengdu 610064,China)  
Objective:To evaluate the ability of the porous nano-hydroapatite crystals and polyamide composite(n-HA/PA66)as scaffold compound with rhBMP-2 to repairing bone defect,study the methods which fast the artificial bone with host bone healing in vivo.Methods:The animal models of bilaterial radius bone defect created with surgery in the New Zealand white rabbits,and were implanted with n-HA/PA66/rhBMP-2 as experimental group,implanted n-HA/PA66 as experimental control group,and no implant as blank control group.The effect were observed by gross X-ray and histopathlogical examination and in situ hybridization at1,2,4,8,12W after operation,and use the spss12.0 and One-Way-ANOVA system to analysis.Results:The defects of experimental group and experimental control group were repair perfectly,The blank control group hadn't repaired after 12weeks,the speed of bone-healing of n-HA/PA66/rhBMP-2 group were faster than n-HA/PA66 group in the early time.The data of in situ hybridization analysis had statistically significant difference between n-HA/PA66/rhBMP-2 and n-HA/PA66 group in two weeks,but the data had no statistically significant difference between n-HA/PA66/rhBMP-2 and n-HA/PA66 group in four weeks.Conclusion:The results show porous scaffold of n-HA/PA66 compound with rhBMP-2 can enhance the ability of the artificial bone with host bone healing in the early time in vivo.
【Fund】: 国家“863”计划(2002AA326020);; 重庆市科委攻关计划资助项目
【CateGory Index】: R318.0;R687.3
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