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《China Biotechnology》 2009-08
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Advances and Applications of Recombinant Antibody Drugs

ZHANG Ying1 HE Jin-sheng1 HONG Tao1,2(1 College of Life Sciences and Bioengineering,School of Science,Beijing Jiaotong University,Beijing 100044,China)(2 Institute for Viral Disease Control and Prevention,China CDC,Beijing 100052,China)  
Recombinant antibody drugs has developed through mice monoclonal antibody(McAb),human-mice chimeric antibody,humanized antibody and full human antibody.They have been applied in clinical immunotherapy for the treatment of cancer,autoimmune diseases,viral diseases and Alzheimer disease,etc.The two basic principles in antibody humanization are keeping or enhancing affinity and reducing immunogenicity of engineered antibodies.The degree of humanization has approached 100% following the continuously improved techniques,such as CDR grafting,resurfacing,antibody library and transgenic mice.However,the gap between the basic research and clinical application still need to be filled.The outline,challenge and perspective in application associated to recombinant antibody drugs were reviewed here.
【Fund】: 国家“863”计划(2006AA02A247)资助项目
【CateGory Index】: R98
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Chinese Journal Full-text Database 8 Hits
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