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《China Biotechnology》 2015-11
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Autophagy and Cancer

JING Yuan-ya;CHEN Ping;CHANG Jian-feng;CHEN Su;School of Life Sciences and Technology,Advanced Institute of Translational Medicine,Research Center for Translational Medicine at East Hospital,Tongji University;School of Forensic Sciences,Xi'an Jiao Tong University Health Science Center;People's Hospital of Zunhua;  
Autophagy is one of the lysosomal degradation pathways,which plays critical roles in multiple physiological processes in eukaryotes.In recent years,it has been believed that autophagy is tightly involved in tumorigenesis and development.The effects of autophagy on cancer are controversial.Autophagy prevents cells from oxidative stress,persistent inflammation,and DNA damage accumulation during carcinogenesis,and eventually inhibits the development of cancer.However,autophagy also provides growth metabolites needed for tumour cells,and maintains the balance of the intracellular environment,thus promoting carcinogenesis.Autophagy also has double-edged effects on cancer therapy:on one hand,induction of autophagy prevents the accumulation of DNA damages and mutations induced by chemotherapy or radiotherapy,and then inhibits cancer progression; on the other hand,autophagy is required for tumor cells to relieve drug and irradiation therapeutic pressures,and potentially contributes to the survival of tumor cells.
【Fund】: 国家自然科学基金(31201051);; 上海市自然科学基金(12ZR1433100 12ZR1433000);; 国家“973”计划(2015CB964800)资助项目
【CateGory Index】: R730
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【Citations】
Chinese Journal Full-text Database 4 Hits
1 XIAO Meng-Jing;LI Li-Gen;Department of Burn and Plastic Surgery, Burn Institute, the First Affiliated Hospital, Chinese PLA General Hospital;;Research progress on autophagy regulating excessive inflammation[J];生理学报;2014-06
2 ZOU Zhengzhi;NIE Peipei;NI Yirong;ZHOU Xiaoming;MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science,College of Biophotonics,South China Normal University;Guangzhou kingmed Diagnostics Corporation;;Thiostrepton induces autophagic cell death in non-small-cell lung cancer cells[J];激光生物学报;2014-01
3 WANG Mei,LI Qing-lin(Research Center,Anhui University of Traditional Chinese Medicine,Hefei,Anhui 230038);Autophagy and the cure of cancer[J];安徽医药;2010-08
4 GE Jun-Na1,HUANG Dan1,XIAO Tian1,WANG Zun1,LI Xiao-Lan2,XIAO Hui2,TAO De-Ding2,GONG Jian-Ping1 1.Department of Gastrointestinal Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei,430030,P.R.China 2.Cancer Research Institute/ Molecular Medical Center,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei,430030, P.R.China;Effect of Starvation-induced Autophagy on Cell Cycle of Tumor Cells[J];癌症;2008-08
【Co-citations】
Chinese Journal Full-text Database 9 Hits
1 GUO Weihong;CHEN Zhaoyu;CHEN Hao;LIN Tian;ZHAO Mingli;LIU Hao;YU Jiang;HU Yanfeng;LI Guoxin;Department of General Surgery,Nanfang Hospital,Southern Medical University;;Sericin regulates proliferation of human gastric cancer MKN45 cells through autophagic pathway[J];南方医科大学学报;2018-02
2 SHAN Yuqiang;WU Yi;YU Panpan;ZHU Akao;KONG Wencheng;ZHENG Sixin;JIN Huicheng;Hangzhou First People's Hospital;Hangzhou Hospital Affiliated to Nanjing Medical University;;Relationship between Susceptibility of Gastric Cancer and Gene Polymorphism of IL-17A[J];激光生物学报;2017-04
3 Meng Runsha;Xu Qiong;Guanghua School of Stomatology,Hospital of Stomatology,Sun Yat-sen University,Guangdong Provincial Key Laboratory of Stomatology;;The research progress on the role of odontoblast in pulp immune response[J];中华口腔医学研究杂志(电子版);2017-04
4 WANG Yuanhang;XIA Shengyuan;ZHANG Lan;GMU-GIBH Joint School of Life Sciences,Guangzhou Medical University;;Becn1 Regulates Cell Apoptosis of Lung Cancer by Mitochondrial Apoptosis Pathway[J];激光生物学报;2017-02
5 YU Jie;YUN Fen;JIA Yong-feng;Inner Mongolia medical university;Department of pathology, the first medical university first affiliated hospital of Inner Mongolia;;The Research of PI3K/AKT Signaling Pathway Related to Tumor Invasion and Metastasis[J];世界最新医学信息文摘;2017-26
6 Du Junhui;Li Rong;Ma Louyan;Hou Pengfei;Depart-ment of Ophthalmology,Xi'an Ninth Hospital;Department of Ophthalmology,The Affiliated Hospital of Xi'an Medical University;;Roles of autophagy in inflammation and eye disorders[J];临床眼科杂志;2017-01
7 JING Yuan-ya;CHEN Ping;CHANG Jian-feng;CHEN Su;School of Life Sciences and Technology,Advanced Institute of Translational Medicine,Research Center for Translational Medicine at East Hospital,Tongji University;School of Forensic Sciences,Xi'an Jiao Tong University Health Science Center;People's Hospital of Zunhua;;Autophagy and Cancer[J];中国生物工程杂志;2015-11
8 Cao Tongtong;Lü rong;Wei Hongchang;Department of Pathlolgy,Shanghai University of Traditional Chinese Medicine;;Nutrient deprivation induced autophagy mechanism and the regulation on cardiovascular disease[J];重庆医科大学学报;2016-04
9 HU Hao;SUN Wei;GU Liu-bao;TU Yue;LIU Hong;Research Institute of Kidney Disease,Nanjing University of Chinese Medicine;Department of Nephrology,Jiangsu Provincial Hospital of Chinese Medicine,The Affiliated Hospital of Nanjing University of Chinese Medicine;Department of Endocrinology,Jiangsu Province Official Hospital;;Molecular mechanism of emodin on inhibiting autophagy induced by HBSS in renal tubular cells[J];中国中药杂志;2015-10
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 HAN Zhong-Bo, ZHANG Peng, FU Qiang, LI Xiao-Lan, GE Jun-Na, TAO De-Ding, HU Jun-Bo, GONG Jian-Ping Cancer Research Institute/ Department of General Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, P. R. China;Inducement of Tumor Cell Autophagy and Cell Cycle Analysis[J];癌症;2006-09
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