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《Acta Biologiae Experimentalis Sinica》 1997-01
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GENE EXPRESSION AND DISTRIBUTION IN MOUSE ABDOMINAL CAVITY MEDIATED BY ADENOVIRUS

WU Hao Quan GENG Yu Hong XU Ren Er YING Bei Bei SUN Jia Tian WAN Yi Bin ZHAO Shou Yuan LI Chang Ben (Institute of Genetics, Fudan University, Statekey Laboratory of Genetic-Engineering, Shanghai 200433)  
Infection and expression of recom-binant human adenovirus in mouse abdominal cavity was reported. After adenovirus vector Ad/RSV-β-gal harboring the E. coli lacZ marker gene was injected into mice abdominal cavity, the peritoneal surface of jejunum, ileum, colon, uterus, liver, spleen, stomach, bladder, abdominal wall, diaphragm and testis was found large patches of lacZ-positive cells. But the adenovirus vector was not able to pene- trate the peritoneum, as demonstrated by histochemical staining. Another adenovirus vector Ad/RSV-tk harboring the HSV-tk gene was injected into mouse abdominal cavity and the mouse was treated with ACV. No acute toxic reaction was observed. Based on these data, the feasibility of gene therapy of malignant tumor within abdominal cavity with adenovirus mediated TK/GCV system was discussed.
【CateGory Index】: Q933
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【Co-references】
Chinese Journal Full-text Database 4 Hits
1 Zhou Chen,Xu Qian(Department of Biochemistry,The First Military Medical Univer-sity,Guangzhou 510515,China).;Recent Advances in the Study of Gene Thera-py.[J];PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS;1995-03
2 Xu Guoheng; Ling Yan; Wan You; Wang Xiaomin; Han Jisheng (Neuroscience Research Center, Beijing Medical University, Beijing);CONSTRUCTION OF RECOMBINANT ADENOVIRUS EXPRESSING HUMAN TYROSINE HYDROXYLASE GENE AND STUDY OF ITS ACTIVITIES IN VITRO[J];CHINESE JOURNAL OF NEUROANATOMY;1998-04
3 LUO Gaoxing, WU Jin, YI Shaoxuan, et al. (Institute of Burn Research,Southwestern Hospital, Third Military Medical University, Chongqing 400038);Prolonging the survival of transplanted alloskin by transferring the CTLA_4Ig locally with recombinant adenovirus vector in mice[J];CHINESE JOURNAL OF BURNS;2000-01
4 Zhang Weiping*,Cao Xuetao,Hamada Hirofumi.*Department of Immunology,Second Military Medical University,Shanghai 200433;Preparation and identification of replicationdeficient human interleukin2 recombinant adenoviruses[J];CHINESE JOURNAL OF MICROBIOLOGY AND IMMUNOLOGY;1998-02
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 CAI Xue-peng,ZHENG Ya-dong,LUO Xue-nong,GUO Ai-jiang(Key Laboratory of Veterinary Parasitology of Gansu Province/State Key Laboratory of Veterinary Etiological Biology/Lanzhou Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Lanzhou 730046);Gene Therapy and Its Applications in Veterinary Medicine[J];Scientia Agricultura Sinica;2007-01
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