Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Acta Biologiae Experimentalis Sinica》 2001-02
Add to Favorite Get Latest Update

EFFECTS OF INTERLEUKIN - 2 ON THE ISOLATED RAT HEART AND THE MECHANISM

WANG Lin Lin SHEN Yue Liang XIA Qiang (Department of Physiology, Zhejiang University, School of Medicine, Hangzhou 310006)  
The purpose of the present study was to explore the biological effects and mechanism of interleukin - 2 (IL -2) on the isolated rat heart. The results showed that hrIL - 2 increased the number of premature ventricular contraction, heart rate, left ventricular developed pressure, left ventricular end - diastolic pressure and coronary flow in the isolated perfused rat heart. Heat inactivated hrIL-2 had no effect on the heart. Pretreatment with ryanodine canceled the positive effects of hrIL - 2 on left ventricular developed pressure, left ventricular end - diastolic pras- sure and coronary flow but had no effects on arrhythmo-genesis and tachycardia by hrIL - 2. Pretreatment with nifedipine or low extracellular calcium abolished the ar-rhythmogenic effect of hrIL - 2 and attenuated partially the augment of heart rate, left ventricular developed pressure, left ventricular end - diastolic pressure and coronary flow. It suggests that the cardiac activity of hrIL - 2 depended on the integrity of its spatial structure and trans-membrane influx Ca 2+ and intracellularly stored Ca2+ were involved in the cardiac activity of hrIL-2.
【Fund】: 浙江省自然科学基金青年人才专项资金资助
【CateGory Index】: R965;
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved