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REAL-TIME QUANTITATIVE PCR ASSAY OF EPSTEIN-BARR VIRUS IN WHOLE BLOOD CELLS OF NASOPHARYNGEAL CARCINOMA PATIENTS

WANG Hai DENG Lin CHEN Su Hong WANG Sheng Qi CAO Ya ( Miner research institute of XiangYa School of Medicine , Central South Unrversty Changsha 410078; Academy of Military Medical Science, Beijing 100000)  
EBV is detected in more and more tumors, and is relative to carcinogenesis. We studied the copies of EBV DNA in whole blood of NPC patients and healthy controls by real lime quantitative PCR In the 73 NPC patients and 83 controls, the positive rale of EBV in blood of NPC is 46.6% , while 13. 3% in control. The mean copy number is 3.9×104 copys/μgDNA in controls, which is much higher than NPC patients (which is 1 7×105 copies/μgDNA). EBV infection is relative with NPC, while the lytic form of EBV maybe more important than its latent form. These results suggest that whole blood EBV DNA may be a valuable tool for molecular diagnosis of NPC.
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