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CHANGES OF SOME IMMUNE-MEDIATORS IN CC1_4-INDUCED LIVER INJURY MICE

ZHU Shan Liang CHEN Long GAO Wei ZHOU Juan (College of Life Sciences, Nanjing Normal University, Nanjing 210097; Key Laboratory of Applied Toxicology, Jiangsu Province, Nanjing 210029; Jiangsu Institute of College, Nanjing 210013, China)  
Changes of some immune-mediators in liver tissue homogenate and plasma of liver injury mice injected with CC14 and its mechanism in the liver injury process induced by CC14 were studied. Thirty healthy mice with half of female and male were chosen and divided randomly into two groups which were control group (group C) and CCl4-injecting group (group CCl4).The liver injury was induced by abdominal injection of CC14 (0.07ml/100g body weight) on every other day over six weeks. The blood and liver were collected at the 2nd, 4th and 6th week, respectively, and liver homogenate cAMP, cGMP levels and MDA concentration as well as plasma IL-2 and TNF-α levels were determined. The results show that during the entire experimental period, cAMP level decreased or markedly decreased in group CC14. After the 2nd week of CCl4-in-jecting, cGMP was lower or significantly lower in group CC14 than in group C; cAMP/cGMP ratio tended to drop, and was low or significantly low to group C; and MDA content was significantly higher in group CC14 than in group C. During the whole experimental period, a marked decrease of plasma IL-2 in group CC14 was seen, and plasma TNF-α of group CC14 was superior to that of group C. It is suggested that the violent changes of immune-mediators including cAMP, cGMP,TNF-α and IL-2 etc induced by CC14 may play an important role in the induction of liver injury in mice.
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