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EFFECT OF WORTMANNIN ON REJOINING OF TELOMERIC DNA STRAND BREAKS

LI Wei Guo1 WANG Kun Ying1 LI Qing Huan2 TAN Zheng2 (1College of Life Sciences, Henan Normal University, Xinxiang 453007, P. R. China; 2The State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, P. R. China)  
Telomeres,which are the DNA-protein complex at the end of eukaryotic chromosome, play an important role in maintaining chromosomal stability, cell senescence and apoptosis. In this work, the effect of wortmannin (WM), an inhibitor of PI-3 kinases, including DNA-dependent protein kinase (DNA-PK), on the rejoining of strand breaks in telomeric DNA induced by H2O2 in HeLa cells was examined. The results show that WM strongly inhibited the rejoining of telomeric DNA strand breaks,and suggest that DNA-PK might be involved in the repair of telomeric DNA damage.
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