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THE EXPRESSION OF GALANIN AND GALANIN RECEPTOR-2 IN THE BRAIN OF CHRONIC STRESS MODEL OF DEPRESSION

YE Yi Lei QI Yan Ting SHAN Liang ZOU Li Juan GAO Liang Cai YUAN Chong Gang~(**) (School of Life Science,East China Normal University,Shanghai 200062,China)  
The expression of galanin and galanin receptor-2 in hippocampus and dorsal raphe nucleus of depression model was studied.The chronic stress rat model was adopted as the modal of depression.Open-field test was used to observe the transformation of their behavior and HPLC- EC was employed to analysis the level of blood serum cortisol.The method of in situ hybridization was used for testing the expression of Galanin and galanin receptor-2 in hippocampus and dorsal raphe nucleus and the method of RT-PCR was used to further analysis of the expression.The re- suits showed that the locomotion activity decreased extremely after chronic stress,but the level of serum cortisol increased evidently.The expression of Galanin and its receptor-2 in hippocampus and dorsal raphe nucleus increased obviously.The higher expression for galanin and galanin recep- tor-2 in some brain area suggested that galanin probably takes part in the modulation of the func- tion of neurons during the stress process.
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