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EXPRESSION PROFILES OF THE GENES ASSOCIATED WITH THE MYOCYTE DIFFERENTIATION DURING RAT LIVER REGENERATION

ZHAO Li Feng~2 ZHANG Ming Zhen~1 XU Cun Shuan~(1**) (~1College of Life Science,Henan Normal University,Xinxiong 453002; ~2Key Laboratory for Cell Differentiation Regulation,Xinxiang 453002)  
Myocytes are important parts of tissues and organs.To study the effects of myocyte differentiation-related genes on rat liver regeneration(LR)at transcriptional level,we obtained these genes through collecting the database data and retrieving the pertinent thesis,and detected the expression profiles of above-mentioned genes during LR using the Rat Genome 230 2.0 array. LR-associated genes were identified by comparing the discrepancy in gene expression changes be- tween partial hepatectomy(PH)group and sham-operation(SO)group,by which 52 LR-associat- ed genes were confirmed.They were classified into 5 groups based on time relevance,including 0.5-1h;2-12h;16h,30h,42h,96h;18-24h,36h,48-60h;66-72h,120-168h,in which the num- bers of up-regulation and down-regulation genes were 8 and 10,24 and 8,21 and 24,53 and 64,28 and 36,respectively.Among these genes,the total 143 times of up-regulation and 136 times of down-regulation,as well as their 8 expression patterns displayed diversity and complexity of the genes associated with the myocyte differentiation.It was inferred that the differentiation of myoblasts and smooth muscle cells were enhanced during LR and the genes associated with the differentiation of skeletal muscle ceils and cardiac muscle cells participated in the cellular physio- logical and biochemical activities of LR.
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