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《Acta Biophysica Sinica》 2013-11
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Advances in the Molecular Mechanism of the Core Circadian Oscillator of Cyanobacteria

CHEN Weiqun;LIU Song;LIU Sen;Institute of Molecular Biology,College of Medical Science,China Three Gorges University;  
Circadian rhythm is a rather generally existing phenomenon in nearly all species on the earth including cyanobacteria.It is widely accepted that circadian rhythm is regulated by circadian clocks,and the circadian clock in cyanobacteria is the simplest one known so far.Although there are many questions remained on the molecular mechanism of the cyanobacterial circadian clock,it is well known that the core oscillator of this circadian clock consists of three proteins(KaiA/KaiB/KaiC),which can form a circadian oscillator independent of transcriptional/translational regulations.In this paper,the authors reviewed the recent researches on the core oscillator of the cyanobacterial circadian clock,including the composition of the circadian clock,the core-oscillator proteins and their interactions,the molecular mechanism of the oscillator,and the future research perspectives.The better understanding of the cyanobacterial circadian clock will be very meaningful to the study of the circadian clocks and related diseases in human.
【Key Words】: Biological oscillator Circadian clock Protein-protein interaction Circadian rhythm
【Fund】: 国家自然科学基金项目(21103098);; 北京分子科学国家实验室开放基金项目;; 三峡大学科研基金项目(2011071001 KJ2012B004)~~
【CateGory Index】: Q945
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1 Peng-Juan Liang;Wen-Yuan Han;Qi-Hong Huang;Yan-Ze Li;Jin-Feng Ni;Qun-Xin She;Yu-Long Shen;State Key Laboratory of Microbial Technology,Shandong University;Archaeal Centre,Department of Biology,University of Copenhagen,Ole Maal es Vej 5,Copenhagen Biocenter,DK-2200 Copenhagen,Denmark;;Knockouts of RecA-Like Proteins RadC1 and RadC2 Have Distinct Responses to DNA Damage Agents in Sulfolobus islandicus[J];遗传学报(英文版);2013-10
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